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University of Southern California (Южно-Калифорнийский университет)

Международная референс-лаборатория
 
Специализация: Старейший исследовательский университет Калифорнии с богатой практикой и научными достижениями, один из самых уважаемых академических медицинских центров США. Клиника предлагает высочайшее качество медицинского обслуживания, обеспечивая предотвращение, диагностику и лечение заболеваний с большей точностью. Ведущие исследователи являются первопроходцами в самых инновационных открытиях в медицине.

MD, Sergei Tatishchev

Anatomic Pathology
 
Специализация: Anatomic Pathology
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EDUCATION AND PROFESSIONAL APPOINTMENTS

EDUCATION

2003 Bachelor of Science, Microbiology, Immunology & Molecular Genetics University of California at Los Angeles (UCLA), Los Angeles, CA

2008 Doctor of Medicine University of Colorado School of Medicine, Denver, CO

POST-GRADUATE TRAINING

2008 - 2010 Anatomic Pathology Beth Israel Deaconess Medical Center, Harvard School of Medicine, Boston, MA

2010 - 2011 Anatomic Pathology Cedars-Sinai Medical Center, Los Angeles, CA

2011 - 2012 Gastointestinal & Liver Pathology Fellowship David Geffen School of Medicine at UCLA, Los Angeles, CA

CLINICAL APPOINTMENTS

2012 - 2015 Staff Pathologist 

UCLA Pathology Outreach, Ronald Reagan Medical Center, Northridge Hospital Medical Center, Olympia Medical Center, PathFinder, Inc Los Angeles, CA

2012 - 2015 Staff Pathologist 

PathKare Laboratory, Inc., Santa Ana, CA

2015 - present Assistant Professor of Pathology 

Keck Medical Center, Department of Pathology Division of Gastrointestinal and Liver Pathology Los Angeles, CA

ADMINISTRATIVE APPOINTMENTS

2012 - 2015 Assistant Director of Telepathology

UCLA Pathology Outreach, Ronald Reagan UCLA Medical Center Los Angeles, CA

2015 - present Director, Digital Pathology and Informatics

Keck Medical Center of USC, Department of Pathology Los Angeles, CA

2019 - present Director, Gastrointestinal and Liver Pathology Fellowship

Keck Medical Center of USC, Department of Pathology Los Angeles, CA

RESEARCH APPOINTMENTS

2003 - 2004 Assistant Researcher (SRA II) 

Department of Medicine, Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA

LICENSURE, CERTIFICATIONS

LICENSURE

2010 A111978, California, Active (Expiration date: October 31, 2021)

BOARD CERTIFICATION OR ELIGIBILITY

2012 Anatomic Pathology, Active

MD, PhD Elena Enbom

Staff Pathologist/Cytopathologist Quest Diagnostics
 
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EDUCATION:

1999-2003: People Friendship University, PhD (Molecular Microbiology and Genetics) Moscow, Russia

1992-1998: I.M. Sechenov Moscow Medical Academy, MD; Moscow, Russia

POSTDOCTORAL TRAINING/RESEARCH EXPERIENCE:

2017- present Staff Pathologist/Cytopathologist Quest Diagnostics, West Hills, CA

2016-2017 Cytopathology Fellowship LAC+USC Medical Center, Los Angeles, CA Program Director: Dr. Felix J.

2015-2016 Women’s Health/Surgical Pathology Fellowship David Geffen School of Medicine at UCLA, Los Angeles, CA Program Director: Dr. Apple S.

2011-2015: Pathology Residency Training Program Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA Program Director: Dr. French S.

2009-2011: Postdoctoral Research Fellowship Department of Pathology and Laboratory Medicine University of Southern California, Los Angeles, CA Principal investigator: Dr. Dubeau L.

2007-2008: Pediatric Residency Training Program (internship) Department of Pediatrics Kaiser Permanente, Los Angeles, CA Program Director: Dr. Woods S.

2006-2007: Postdoctoral Research Fellowship Department of Hematology and Oncology Children’s Hospital of Los Angeles, Los Angeles, CA Principal investigator: Dr. Reynolds P.

2000-2005: Postdoctoral Research Fellowship Department of Microbiology University of Washington, Seattle, WA Principal investigator: Dr. Sokurenko E.

1998-2000: Obstetrics and Gynecology Residency Training Program Department of Obstetrics and Gynecology People Friendship University, Moscow, Russia Program Director: Dr. Radzinsky V.

CERTIFICATIONS:

Anatomic and Clinical Pathology Board

Date certified: July 18, 2016

Cytopathology Board

Date certified: August 31, 2017

MEMBERSHIPS IN PROFESSIONAL ORGANIZATIONS:

United States and Canadian Academy of Pathology (USCAP)

American Society for Clinical Pathology (ASCP)

College of American Pathologists (CAP)

Editorial Board, Austin Journal of Clinical Pathology

BIBLIOGRAPHY:

1. E. Enbom, E. Yung, J. Felix. Unsatisfactory Liquid- Based Cytology Specimens and their correlation with HPV status in cervical cancer screening. USCAP 2017.

2. E. Enbom, P. Abasolo, L. Nikolaenko, X. Qing, G. Duane. Cytomorphology of Hepatic Epitheliod Hemangioendothelioma Cells in Ascitic Fluid. ASCP Annual meeting 2013, October.

3. E. Enbom, Mary Le, L. Oesterich, S.W.French. Dual Mechanism of Hepatotoxicity due to Cimicifuga racemosa (Black Cohosh): histopathological and ultrastructural studies of liver biopsy. ASCP Annual meeting 2013, October.

4. Mary D. Le, E. Enbom, Peter K. Traum, Valentina Medici, Charles H. Halsted, and Samuel W. French. Histopathologic Changes in Alcoholic Liver Disease Patients Treated with S-adenosyl-L-methionine. Annual ASIP meeting 2012, April.

5. Mary D. Le, E. Enbom, Peter K. Traum, Valentina Medici, Charles H. Halsted, and Samuel W. French. Histopathologic Changes in Alcoholic Liver Disease Patients Treated with S-adenosyl-L-methionine: An In-depth Look at Data from a Double-Blinded, Randomized, Placebo-Controlled Trial. 102nd USCAP meeting 2013, March.

6. E. Enbom, J. Dixon, X. Qing, N. Sun. Plasmablastic Lymphoma: A 49-Year-Old Man with HIV Infection and an Intracardiac Mass. Annual LASOP residents and fellows poster presentation, 2013 March.

7. Sahar Soleymani, E. Enbom. Not Your Typical Sub-sternal Chest Pain. SGIM 36th Annual Meeting 2012, April.

8. Leslie Oesterich, MD, E. Enbom, Maria Dungo. A Most Unusual Headache: TTP as the Diagnostic Marker for a Case of SLE. Annual UCLA poster presentation 2012, May.

9. E. Enbom, Ying Liu, Louis Dubeau. Differential Regulation of Expression of GRP78 and GRP94 by BRCA1 During Ovarian Follicular Development. 101st USCAP meeting 2012, April.

10. Ying Liu, E. Enbom, Hai-Yun Yen, Robert Maxson, Louis Dubeau. Role of the mullerian ducts in the development of genito-urinary organs and coelomic epithelial tissues in female mice. AACR meeting 2010, April.

11. E. Trinchina, E. Sokurenko, Mana Obata-Yasuoka, Scott Weissman, J. Lohnson, D. Dykhuizen. Clonal diversification of the Escherichia coli O18/O1/O2:K1:H7 complex is driven by adaptation to the vaginal niche. 104th ASM meeting. 2004 May1(1).

12. Sokurenko E.V., Tchesnokova V., Thomas W.E., Trinchina E., Forero M., Vogel V. Shear-force activation of the Esherichia coli FimH adhesion depends on structural integrity of the pilin domain. 104th ASM meeting. 2004 May1(1).

13. Makoto Kuroda, P. Aprikian, Scott Weissman, Trinchina E., Daniel Dykhuizen. Within-clonal pathoadaptive microevolution of extra-intestinal E. coli. 104th ASM meeting. 2004 May1(1).

14. Michael Feldgarden, W. Thomas, Trinchina E., E. Sokurenko, Scott Weissman, J. Johnson. Adaptive SNPs in the type 1 fimbrial adhesion of Escherichia coli serotype O18:K1:H7. 103d ASM meeting. 2003 May 1(1).

15. Sokurenko E.V., Tchesnokova V., Thomas W.E., Trinchina E., Forero M., Vogel V. Reconstitution of shear activated adhesion of Esherichia coli by using purified bacterial fimbriae and their receptors. 103d ASM meeting. 2003 May 1(1).

16. Sokurenko E.V., Tchesnokova V., Thomas W.E., Trinchina E., Forero M., Vogel V. Shear enhances binding of E. coli to model receptors of the type 1 fimbrial adhesin FimH. 103d ASM meeting. 2003 May 1(1).

17. Dykhuizen D., Feldgarden M., Trinchina E., Avakyan S., Johnson J., Sokurenko E. The adaptive evolution of type 1 fimbriae in E. coli associated with certain extraintestinal diseases. 102nd ASM meeting, Salt Lake City, Utah, May, 2002.

18. Weissman S., Trinchina E., Feldgarden M., Dykhuizen D., Johnson J., Sokurenko E. Adaptive evolution of the type 1 fimbrial adhesin, FimH, leads to increased adhesiveness and clonal diversification of Escherichia coli O18:K1:H7 isolates. 102nd ASM meeting, Salt Lake City, Utah, May, 2002.

19. S. Avakyan, D. Dykhuizen, M. Feldgarden, E. Trinchina, E. Sokurenko. The adaptive evolution of type 1 fimbriae in E. coli associated with certain extraintestinal diseases. 102nd ASM meeting, Salt Lake City, Utah, May, 2002.

20.Thomas W.E., Trinchina E., Forero M., Vogel V., Sokurenko E.V. Mechanical shear enhances adhesiveness of the Escherichia coli mediated by the type 1 fimbrial adhesin FimH. 102nd ASM meeting, Salt Lake City, Utah, May, 2002.

21. Sokurenko E.V., Trinchina E., Schembri M.A., Kjaergaard K., Hasty D.L., Klemm P. Characterization of recombinant type 1 fimbrial adhesins of Escherichia coli with enhanced monomannose-specificity but lost oligimannose-specificity. 100th ASM meeting, Los Angeles, California, May, 2000.

22. Chesnokova V., Trinchina E., Kravtzov E. The role of adhesiveness of E. coli M17 – the producing strain for an eubiotic preparation “Kolibacterin” – in bacterial colonization. 6th Annual International Ain Shams Medical Students’ meeting, Cairo, Egypt, 1998.

23. Chesnokova V., Trinchina E., Yermolaev A. Methods of genetic engeneering in eubiotic E. coli strain modification. 3rd International Medical Students’ meeting. Katowice, Poland. 1997

Publications:

1. E. Enbom, N. A. Moatamed. Significance of routine vaginal cytological screening in cases with and without clinical symptoms for procedural evaluation of the uterine lesions (in preparation).

2. E. Enbom, J. Felix. Unsatisfactory Liquid- Based Cytology Specimens and their correlation with HPV status in cervical cancer screening (in preparation).

3. E. Enbom, Ying Liu, Louis Dubeau. Ovarian cancerogenesis and ER stress (in preparation).

4. Qing X, Enbom E, Qing A, French S, Cai J. Plasmablastic lymphoma presenting as a large intracardiac mass and bilateral pleural effusions. Exp Mol Pathol. 2016 Feb;100(1):79-81.

5. Liu Y, Pike MC, Wu N, Lin YG, Mucowski S, Punj V, Tang Y, Yen HY, Stanczyk FZ, Enbom E, Austria T, Widschwendter M, Maxson R, Dubeau L. Brca1 Mutations Enhance Mouse Reproductive Functions by IncreasingResponsiveness to Male-Derived Scent. PLoS One. 2015 Oct 21;10(10)

3. E. Enbom, P. Abasolo, J. Dixon, S. French, G. Duane. Cytomorphological features of epithelioid hemangioendothelioma in ascitic fluid with radiological, clinical and histopathological correlations. Acta Cytol. 2014;58(2):211-6

4. S. French, E. Enbom. Piecemeal necrosis of the liver revisited: a review. Exp Mol Pathol. 2014 Jun;96(3):307-309.

5. E. Enbom, Mary Le, L. Oesterich, S. French. Mechanism of hepatotoxicity due to Cimifuga Racemosa (Black Cohosh): histopathological and ultra-structural studies of liver biopsy specimens. Exp Mol Pathol. 2014 Jun;96(3):279-83

6. Mary D. Le, E. Enbom, Peter K. Traum, Valentina Medici, Charles H. Halsted, and Samuel W. French. Alcoholic Liver Disease Patients Treated with Sadenosyl-L-methionine: An In-depth Look at Liver Morphologic Data Comparing Pre and Post Treatment Liver Biopsies. Exp Mol Pathol. 2013 Oct;95(2):187-91

7. Aprikian P., Tchesnokova V., Kidd B., Yakovenko O., Yarov-Yarovoy V., Trinchina E., Vogel V., and Thomas W. Interdomain interaction in the FimH adhesion of Escherichia coli regulates the affinity to mannose. JBC. 2007 August, 282(32): 23437-46

8. Beskhlebnaya V.A., Trinchina E., Aprikyan P., Chesnokova V. and Sokurenko E.V. Molecular genetic analysis of Escherichia coli type I adhesins. Bull Exp Biol Med. 2006 March; 141 (3):339-42

9. Nilsson L.M., Thomas W.E., Trinchina E., Vogel V., Sokurenko E.V. Catch bondmediated adhesion without a shear threshold: trimannose versus monomannose interactions with the FimH adhesin of Escherichia coli. J. Biol. Chem. 2006, Apr 16

10.Sokurenko EV, Feldgarden M, Trinchina E., Weissman SJ, Avagyan S, Chattopadhyay S, Johnson JR, Dykhuizen DE. Selection footprint in the FimH adhesin shows pathoadaptive niche differentiation in Escherichia coli. Mol Biol Evol. 2004 Jul;21(7):1373-83.

11. Trinchina E. Structural and functional study of the receptor binding site for FimH adhesin in uropathogenic strains of Escherichia coli. Bull Exp Biol Med. 2003 Oct;136(4):380-4.

12. Wendy E. Thomas, Trinchina E., Manu Forero, Viola Vogel, and Evgeni V. Sokurenko. Bacterial adhesion to target cells enhanced by shear force. Cell. 2002, 109(7):913-923

13. Sokurenko E.V., Schembri M.A., Trinchina E., Kjaergaard K., Hasty D.L., Klemm P. Valency conversion in the type 1 fimbrial adhesin of Escherichia coli. Mol.Microbiol. 2001, 41(3):675-86

14. Johnson J.R., Weissman S.W., Stell A.L., Trinchina E., Dykhuizen D.E., Sokurenko E.V. Clonal and pathotypic analysis of archetypal Escherichia coli cystitis isolate NU14. J.Infect. Dis. 2001, 184(12):1556-65

15. Sokurenko E.V., Tchesnokova V., Yeung A.T., Oleykowski C.A., Trinchina E., Hughes K.T., Rashid R.A., Brint J.M., Moseley S.L., Lory S. Detection of simple mutations and polymorphisms in large genomic regions. Nucleic Acids Res. 2001, 29(22): E111

16. Kuz’mina G., Kravtzov E, Trinchina E., Ermolaev A. Resistance of different types of Probiotics to gastric acid, and its improvement by some technological solutions. Biomed. Technologies. Ed 2. 1995

Dr. Adam Cloe

Hematopathology
 
Специализация: Anatomic and Clinical Pathology, Hematopathology
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Certifications

Board certifications:

Anatomic and Clinical Pathology, 2017

Hematopathology, 2018

Work History

  • Staff Pathologist, Quest Diagnostics, 2019-Present.

  • Review and sign out general surgical specimens, peripheral blood smears and body fluids

  • As one of two board-certified hematopathologists, provide specialty consultation for all specimens with concern for hematolymphoid disease

  • Perform quality control for general pathology specimens

  • Communicate with clinicians to provide clinicopathological correlation and resolve questions regarding diagnoses

  • Assist in quality improvement projects with laboratories

Education

Fellowship. City of Hope, Hematopathology fellow, 2017-2019

Residency. University of Chicago, Pathology Department, 2013-2017

M.D. University of Chicago 2005-2013

Ph.D. University of Chicago, Biological Sciences Division, Committee for Molecular Pathology and Molecular Medicine 2005-2011

B.A. Boston University, Biochemistry and Molecular Biology 2000-2004

Research Experience

•    Undergraduate Research Assistant, Boston University 01/2003-05/2004

My undergraduate research was focused in Dr. Michael Baum’s neuroendocrinology laboratory. My research focused on the importance of the vomeronasal organ in the ability to detect pheromones in ferrets.

•    Laboratory Technician, Spanish National Cancer Center 07/2004-06-2005

At the Spanish National Cancer Center I worked in the laboratory of Dr. Mariano Barbacid, the director of the center. I was instrumental in the genotyping and maintenance of research mice and also worked on developing new laboratory techniques.

•    PhD Thesis, University of Chicago 08/2007-05-2011

My research in Dr. Stephen Meredith’s laboratory focused on studying different mutants of the A-beta protein, and determining their biophysical features. My work also touched intimately on the issue of identifying the toxic forms of A-beta aggregates.

Memberships and Awards

•       Boston University Alumni Award for Writing in the Natural Sciences (2004)

•       University of Chicago Medical Scientist Training Program (2005-2013)

•       Graduate Medical Education Committee, Pathology Resident Representative, University of Chicago, (2014-2015)

•       American Physician Scientist Association (2007-Present)

•       United States and Canadian Academy of Pathology (2013-Present)

•       College of American Pathology (2013-Present)

•       Chicago Pathology Society (2014-2017)

•       Los Angeles Society of Pathology (2017-Present)

Additional Projects

Consultant, Becker Professional Education

During my fourth year of medical school I was hired by Becker Professional Education as a consultant for the test preparation materials for the USMLE Step 1 test. I initially reviewed their pathology notes and transitioned to writing and revising questions for their question bank. I continue to occasionally review new questions and educational materials and respond to questions sent in by students using the Becker question bank. I also lead online lectures reviewing hematology (benign and malignant) and general oncology lectures for students preparing for the USMLE Step 2 CK exam.  

Publications/Abstracts

Xie W, Tang G, Wang E, Kim Y, Cloe A, Shen Q, Zhou Y, Garcia-Manero G, Loghavi S, Hu AY, Wang S, Bueso-Ramos CE, Kantarjian HM, Medeiros LJ, Hu S. t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm? Ann Hematol. 2020 Mar;99(3):487-500. doi: 10.1007/s00277-020-03909-7. 

Cheng JX, Chen L, Li Y, Cloe A, Yue M, Wei J, Watanabe KA, Shammo JM, Anastasi J, Shen QJ, Larson RA, He C, Le Beau MM, Vardiman JW. RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat Commun. 2018 Mar 21;9(1):1163. doi: 10.1038/s41467-018-03513-4. 

Cloe AL, Pillai RK, Telatar M, Weisenberger DD, Kuo J, Hooie Y, Aoun PA and Afkhami M. A Novel Fusion of TCF3-MEF2B in BCR-ABL Negative B-Lymphoblastic Leukemia. USCAP 2018

Cloe, AL, Chen Li, Li Yuan, Liu Hongtao and Cheng, Jason X. Identification of Specific Hnrnps As Novel Therapeutic Targets and Responsive Indicators of KPT330 (Selinexor) in Leukemia. ASH 2016 Cloe AL, Johnson DN, Von Slambrouck C and Cheng J. AXL, a Potential Biomarker in the Progression of Monocytic Leukemia. USCAP 2015

Cloe AL, Orgel JPRO, Sachleben JR, Tycko R, Meredith SC. The Japanese Mutant Aβ (ΔE22-Aβ1–39) Forms Fibrils Instantaneously, with Low-Thioflavin T Fluorescence: Seeding of Wild-Type Aβ1-40 into Atypical Fibrils by ΔE22-Aβ1-39. Biochemistry. 2011; 50(12): 2026-2039.

Cloe AL, Woodley SK, Waters P, Zhou H, Baum MJ, Contribution of anal scent gland and urinary odorants to mate recognition in the ferret. Physiology & Behavior. 2004; 82 (5): 871-875.

Woodley SK, Cloe AL, Waters P, Baum MJ. Effects of Vomeronasal Organ Removal on Olfactory Sex Discrimination and Odor Preferences of Female Ferrets. Chemical senses. 2004; 29(8): 659-669.